Polymeric Matrices for Neural Graft Transplantation

One of the main issues in neural grafting technology is the optimization of graft survival and integration into the host brain, prerequisites for the establishment of a functional host-graft relationship. Optimal integration of the transplanted cells is the result of axonal growth from the transplant and the regeneration of axons from host neurons damaged during the transplantation procedure. Glial cells at the graft-host interface should not be allowed to obstruct the growth of fibers. We propose a grafting strategy (Figure 1) involving the incorporation of neural cells into highly porous polymeric matrices (i.e. macroporous hydrogel (Step 1 of Fig. 1)which display three functions converging toward promoting neural graft integration: